PGT

Preimplantation Genetic Testing (PGT)

Preimplantation genetic testing (PGT) offers an alternative for these couples, where the genetic test is performed on the embryos before transfer (Preimplantation embryo). In PGT, couples go through routine IVF/ICSI procedures to generate embryos in vitro, the day-5 embryos (Blastocyst) are biopsied, and the genetic test is performed on the biopsied cells. Later normal embryo is transferred. Abnormal embryos usually destroy depends on mosaicism. But that doesn’t mean that all couple need PGT. PGT should be reserved for few couples with certain clinical conditions.

Who needs PGT?

How is PGT Done?

PGT involves the screening of embryos created through IVF to identify genetic abnormalities or chromosomal disorders
Embryo biopsy- A small sample of cells is extracted and analyzed from each embryo for genetic analysis
The results of PGT can help identify the healthiest embryos for transfer to the uterus

What are the Disadvantages of PGT?

Not many standard large research studies available for the use of PGT for routiene clinical practice. That’s why PGT use should be limited for indicated patient only. More recently some research has proposed the possibility of transferring some types of mosaic embryo (Abnormal ) with the result of healthy newborn. These incidences insist us to rethink that are we destroying normal embryos thinking that they are abnormal.

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PGT